Системски лупус еритематодес ( СЛЕ ) е хронична воспалителна автоимуна болест кај која имунолошкиот систем на телото по грешка го напаѓа здравото ткиво.
СЛЕ е најчест кај жени помеѓу 10 и 50 годишна возраст. Болеста често предизвикува болки и оток во зглобовите, артритис, губење на косата, рани на устата, чувствителност на сончева светлина, хроничен замор и болки во градите. Текот на болеста може да биде непредвидлива, со периоди на влошување и наизменично со ремисија. Се проценува дека од СЛЕ се болни преку 5 милиони луѓе. СЛЕ се карактеризира со празнење и зголемување на Тх17 клетки, Т и Б лимфоцити - во присуството на автоантитела. Регулаторните Т-клетки (Tregs ) се клетки кои го модулираат имуниот систем. Тх17 клетките играат улога при воспалението и оштетувањето на ткивата кај автоимуните болести. Меѓу факторите од животната средина за кои се смета дека придонесуваат и се причина за СЛЕ се: сончевата светлина, стресот, хормоните, чадот од тутун и разни вируси - особено Epstajn -Barr вирусот (EBV). Исто така, некои лекови (антиепилептици, лекови за крвен притисок, антибиотици, хормони) кај подложни поединци може да предизвикаат СЛЕ. Во т.н. “ лек - индуциран lupus erythematosus “ симптомите обично исчезнуваат целосно по прекинот на соодветните лекарства.
СЛЕ и Витамин Д3
Во светот постои епидемија на недостаток на витамин Д, особено во поголемиот дел од не - екваторското население. Денес е познато дека недостатокот на витамин Д е голем фактор во патологијата на многу заболувања, вклучувајḱи ги и автоимуните заболувања; вродените дефекти; ракот ( најмалку 17 видови ); кардиоваскуларните болести; хроничната болка; депресија; диабетес; мускулна слабост; остеоартритис и периодонтитис .
Повеќе студии покажале дека пациентите со системски лупус еритематодес (СЛЕ) имаат ниско ниво на витамин Д3. Пациентите имаат посериозни симптоми кога е присутен недостаток на Д витамин. Овие студии покажаа ефект на зголемување на витамин Д3 Трегс и намалување на клетки Тх1 и Тх17. Што е уште поважно, постои директна корелација помеgѓу тежината на симптомите на болеста и нивото на витамин Д, што е најверојатен доказ дека недостатокот на витаминот Д е директно вмешан во патогенезата на оваа тешка болест. За време на зимските месеци има помалку сонце на располагање, па луѓето обично имаат пониско ниво на витамин Д во крвта.
За да се „извлече“ најголема корист од витаминот Д, телото треба да има и други ко-фактори како: магнезиум, витамин К, цинк, бор и витамин А.
Витаминот Д го контролира калциумот во крвта, коските и цревата и помага за клетките на целото тело да можат правилно да комуницираат. Ако е кожата изложена на сонце, таа произведува витамин Д и го праќа до црниот дроб. Ако се земе додатно или со храна која содржи витамин Д, стомакот, исто така испраќа витамин Д до црниот дроб, каде што овој витамин се менува во една супстанца наречена 25(ОХ)Д3. Така е наречен и тестот за утврдување на нивото на Д 3 во крвта. Активираниот витамин Д сега е подготвен да ги врши своите функции:
- Одржување на нивото на калциум во крвта, коските и цревата
- Клетките правилно да комуницираат по целото тело
На површината на клетката се наоѓаат Витамин Д рецептори, каде што тие добиваат хемиски сигнали, па така витаминот Д може да се врзе за овие рецептори. Ова може да доведе до намалување на автоантителата и така да престанат нападите врз здравите клетки.
Влијанието на Curcumin (Куркумин) Куркума врз СЛЕ
Новите истражувања покажуваат дека куркуминот, има силни анти - воспалителни и анти - артритични својства, со дејство на повеḱе од 700 гени, во синтеза на циклооксигеназа -2 ( COX-2) и 5 - липоксигеназата (5- ензимот LOX ), како и на други ензими кои се вклучени во инхибицијата на воспалението. Многу е тешко да се постигне ефектот на терапијата со куркумин ако се користи обичен куркумин во прав. Добра алтернатива е да се направи микроемулзија со комбинирање на куркумин во прав со жолчки од јајце и стопено кокосово масло.
Исхрана – диета
Во период од две или три недели, од исхраната треба да се елиминираат заедничките алергени (како што се пченица, јајца, млеко, кикирики и пченка).
Акупунктурата може да биде корисна за ублажување на болки кои се поврзани со лупус.
Традиционална кинеска медицина (TCM):Moxibustion (загревање) и акупунктура на следните точки: Zusanli-ST36 , ST41-JieXi , Dazhui-GV14 und ShiQiZhuiXia-M-BW-25 , Shenshu-BL23, BL18-Ganshu, Danshu-BL19, LI-4, GV-14, KI-7, SP-6, GB-20, San Yin Jiao (Sp 6),Jue Gu (GB 39), Zhao Hai (Ki6), Xue Hai (Sp 10),Ming Men (Du 4), Guan Yuan(Ren 3), Shen Shui (UB 23),Tai Xi (Ki 3).
Омега-3-масникиселини
Со повеќе студии е докажано дека омега-3 масните киселини го намалуваат воспалението кај пациентите со СЛЕ. Најмалата дневна потреба на -3 масни киселини eicosapentanoic киселина (EPA) е 180 мг, а за docosahexanoic киселина (DHA) е 120 мг. Настапува намалување на арахидонската киселина, која е обично висока кај СЛЕ. Повисоки дози покажуваат дополнителен позитивен ефект врз нивото на холестеролот.
Бета-глукан
Тоа е долголанчан полисахарид кои има својство на активација на имуниот систем. Обично се добива од квасец Saccharomyces cerevisiae. Во природата се наога во житарици - зоб, јачмен, во Reishi печурките (Ganoderma lucidum), Chaga (Inonotus obliquus), Shiitake (Lentinula edodes) i Maitake (Grifola frondosa), кај(Hericium erinaceus), Cordyceps(Cordyceps militaris) и во некои врсти на алги.
Печурките имаат т.н. имуномодулаторен ефект. Дејството на печурките се подобрува во присуство на витаминот Ц.
Истражувањата покажаа дека бета - глуканот во телото активира клучни имунолошки клетки - фагоцити, макрофаги, неутрофили, еозинофили и д-р.
Ингвер, Витамин А, Е, Б6 имаат позитивно делување на СЛЕ.
Ланено семе
Лененото семе содржи масни киселини како алфа - линоленска киселина, која може да делува за намалување на воспаленијата во телото. Некои истражувања покажаа дека функцијата на бубрезите може исто така да се подобри кај СЛЕ.
Масажа, хиропрактика, јога, медитација и хидротерапија
Масажата може да ја подобри циркулацијата и може де биде корисна кај хронични зглобни и мускулни болки.Третманот може де вклучи и хербална терапија.
За да се постигне најдобар ефект од алтернативното лекување потребно е следново:
- Амалгамските пломби да се одстранат.
- Да се избегнува внесување на флуориди, алфалфа производи, преработена храна, рафинирани шеḱери, хемиски модифицирана храна / хемиски адитиви, газирани пијалоци и кафе во организмот.
- Пушењето е строго забрането.
Литература;
1 Lupus Foundation of America . What is Lupus? , 2014. Web . Accessed 1 Februar 2014. <http://www.lupus.org/answers/entry/what-is-lupus>
2 National Institutes of Health. Systemic lupus erythematosus. Year 2014. Web.Abgerufen 1 Februar 2014. <Http://www.nlm.nih.gov/medlineplus/ency/article/000435.htm>
3 Alele JD & DL Kamen . The importance of the vitamin D status and inflammation in SLE -associated osteoporosis. Autoimmunity Reviews 2010 ; 9:137-9 .
4 WebMD. Lupus Health Center . , 2011. Web . Accessed 1 Februar 2014. <http://www.webmd.com/lupus/guide/lupus-systemic-lupus-erythematosus-cause>
5 Antico A, Tampoia M, R & Tozzoli Bizzaro N. vitamin D may reduce the risk or to change the course of autoimmune diseases ? A systematic review of the literature . Autoimmunity Reviews 2012 , 12:127-136 .
7 Breslin LC, Magee PJ , JMW Wallace & EM McSorley . An evaluation of the vitamin D status in individuals with systemic lupus erythematosus. Proceedings of the Nutrition Society 2011 , 70:399-407 .
8 Terrier B Derian N Schoindre Y, et al. Recovering the regulatory and effector T -cell balance, and B-cell homeostasis in systemic lupus erythematosus patients with vitamin D supplementation. Arthritis Research & Therapy 2012 , 14 ( R221 ) :1- 10th
9 Hiraki LT, Munger KL , Costenbader KH, et al. Intake of vitamin D during adolescence and the risk of adult-onset diabetes systemic lupus erythematosus and rheumatoid arthritis. Arthritis Care & Research 2012; 62 (12 ) :1829 - 1836.
10 Mok CC , Birmingham DJ, Leung HW , et al. Vitamin D levels in Chinese patients with systemic lupus erythematosus : relationship with disease activity , vascular risk factors and atherosclerosis. Rheumatology 2012; 51:644-652 .
11 Pelajo CF , Lopez- Benitez JM & Miller LC. Vitamin D and autoimmune rheumatic diseases . Autoimmunity Reviews 2010 , 9:507-510 .
12 Kamen DL , Cooper GS, Bouali H, et al. Vitamin D deficiency in systemic lupus erythematosus . Autoimmunity Reviews 2006; 5:114-7 .
13 Birmingham DJ, Hebert LA , Song H, et al. Evidence that unusually large seasonal decline in vitamin D status may SLE flare in non-African Americans auslösen.Lupus 2012 , 21 ( 8) , 1-18 .
14 Sakthiswary R & Raymond AA . The clinical importance of vitamin D in systemic lupus erythematosus : A systematic review . PLoS One , 2013, 8 ( 1) :1- sixth
15 Abou- Raya A, Abou- Raya S & Helmii M. The effect of vitamin D supplementation on inflammatory and hemostatic markers and disease activity in patients with systemic lupus erythematosus : a randomized , placebo-controlled Studie.Journal of Rheumatology 2013 ; 40 :265 - 272.
16 Cutillas -Marco E, A Marquina Vila , Grant WB , et al. Vitamin D and cutaneous lupus erythematosus : effect of vitamin D replacement on the severity of the disease . Lupus 2014 0:1-9 .
17 Lertratanakul A, P , Wu , A. Dyer et al. 25 -hydroxyvitamin D and cardiovascular disease in patients with systemic lupus erythematosus : data from a large international cohorts. Arthritis Care & Research , 2014. Accepted Article , doi: 10.002/acr.22291 .
Текстот го напишал:
Д-р на мед. науки Борис Банг Војдановски
Обработил:
Јордан Стефановски
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